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KMID : 0861020160310050099
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Korea Journal of Herbology
2016 Volume.31 No. 5 p.99 ~ p.106
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Effects of Salvianolic Acid B Against Oxidative Stress in Skeletal Muscle and Brain Tissue following Exhaustive Exercise in Rats
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Lee Hyun-Joon
Kang Sung-Han
Kweon Su-Hyeon
Kim Dae-Kyung
Kim Jee-ho
Moon Ji-Hong
Shin Jung-Won
Lee Jong-Soo
Sohn Nak-Won
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Abstract
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Objectives : Salvianolic acid B (SAB) is an active ingredient in Salvia miltiorrhiza frequently used for cardiovascular and cerebrovascular diseases. The present study investigated the antioxidant effects of SAB on the skeletal muscle and the brain tissue of rats following exhaustive exercise.
Methods : The rats were treated with oral administration of SAB (30 mg/kg) daily for 5 days prior to the exhaustive exercise. The exhaustive exercise was performed as swimming for 150 min with 5% body weight attached to the tail on the 5th day. The antioxidant effects of SAB was evaluated by measuring the superoxide generation in the gastrocnemius and the 4-HNE expression in the hippocampal tissue. In addition, c-Fos-expressing cells in the brain tissue was observed using immunohistochemistry.
Results : Histological features and muscle fiber type composition were not different between the SAB group and the exhaustive exercise group. SAB significantly reduced the upregulation of superoxide generation in the muscle tissue. SAB significantly reduced the increase of c-Fos-expressing cells in the cerebral cortex, paraventricular thalamic nucleus, dorsomedial hypothalamic nucleus, the CA1, CA3, and DG regions of hippocampus. SAB significantly reduced the upregulation of 4-HNE expression in the CA1 and DG regions of hippocampus caused by the exhaustive exercise.
Conclusions : The results suggest that SAB exerts antioxidative effect against oxidative stress in the skeletal muscle and the brain tissue following exhaustive exercise, while SAB may has an anti-stress effect on stress responses in the brain.
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KEYWORD
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Salvianolic acid B, Oxidative stress, Skeletal muscle, Brain tissue, Exhaustive exercise, Superoxide, c-Fos
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